Professor Dr. Tirayut Vilaivan


Contact Information:

Department of Chemistry, Faculty of Science
Chulalongkorn University
Phayathai Road, Patumwan
Bangkok 10330, THAILAND


Office: 1340 Mahamakut Building
Tel: 02-2187627 ext 101
Fax: 02-2187598



Personal Home Page:   N/A

Teaching/Research Field:

Organic Chemistry

Research Unit(s):

Organic Synthesis Research Unit



Current Research Topics:

·        Synthesis and nucleic acid binding properties of Peptide Nucleic Acids (PNA)

·        Development of novel synthetic methodologies (esp. catalytic asymmetric synthesis)

·        Development of novel antimalarials based on Dihydrofolate Reductase inhibitors

Research Highlights: 2011-2012



·        1992 B.Sc. (Chemistry), Chulalongkorn University, THAILAND

·        1996 D.Phil (Organic Chemistry), Oxford University, UK


Work Experiences:

·        1996-1999 Lecturer, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, THAILAND

·        1999-2004 Assistant Professor, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, THAILAND

·        2004-2011 Associate Professor, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, THAILAND

·        2012-present Professor, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, THAILAND


Professional Services:

·        Membership Thai Academy of Science and Technology Foundation (Associate member: 2004-2006, Elected Member Oct 2006-present), American Chemical Society (2006-present), Science Society of Thailand, Chemical Society of Thailand.

·        International Editorial Advisory Board: Chemistry – An Asian Journal  (2010-present)

·        Scientific Committee, Chemical and Pharmaceutical Sciences Division, National Research Council of Thailand (Oct 2012-present)


Selected Scholarship and Awards:

·        Apr–Sep 1998 Royal Society Research Fellowship (Dyson Perrins Laboratory, Oxford under supervision of Prof. G. Lowe, FRS) and visiting research fellow at Lincoln College, Oxford

·        2000 National Young Scientist Award (Science and Technology Promotion Foundation under patronage of HM King Bhumipol)

·        2009 CST Award for Distinguished Young Chemist 2008 (Chemical Society of Thailand)

·        2009–2011 Alexander von Humboldt fellowship for experienced researcher (Prof. Dr. Oliver Reiser (Regensburg) and Prof. Dr. Hans-Achim Wagewnknecht (Regensburg/Karlsruhe)

·        2009 TRF Senior Research Scholar (the Thailand Research Fund)

·        2011 National Distinguished Researcher 2010 (Chemical and Pharmaceutical Sciences) (National Research Council of Thailand)


Publications: (updated June 2013)

84.        Ulbrich, K.; Kreitmeier, P.; Vilaivan, T.; Reiser, O. “Enantioselective Synthesis of 4-heterosubstituted cyclopentenones” J. Org. Chem. 2013, 78, 4202–4206. (on-line: 01 Apr 2013, published: 19 Apr 2013) (DOI: 10.1021/jo400409f)

83.        Ditmangklo, B.; Boonlua, C.; Suparpprom C.; Vilaivan T. “Reductive alkylation and sequential reductive alkylation-click chemistry for on-solid-support modification of pyrrolidinyl peptide nucleic acid” Bioconjugate Chem. 2013, 24, 614–625. (on-line: 08 Apr 2013, published: 17 Apr 2013) (DOI: 10.1021/bc3005914)

82.        Vilaivan, C.; Srinarang, W.; Yotapan, N.; Mansawat, W.; Boonlua, C.;Kawakami, J.; Yamaguchi, Y.; Tanaka, Y.; Vilaivan, T. “Specific recognition of cytosine by hypoxanthine in pyrrolidinyl peptide nucleic acid” Org. Biomol. Chem. 2013, 11, 2310–2317. (on-line: 31 Jan 2013, published: Mar 2013) (DOI: 10.1039/c3ob27129c)

81.        Sankoh, S.; Samanman, S.; Thipmanee, O.; Numnuam, A.; Limbut, W.; Kanatharana, P.; Vilaivan, T.; Thavarungkul, P. “A comparative study of a label-free DNA capacitive sensor using a pyrrolidinyl peptide nucleic acid probe immobilized through polyphenylenediamine and polytyramine non-conducting polymers” Sens. Actuators B: Chem. 2013, 177, 543–554. (on-line: 30 Nov 2012, published: Feb 2013) (DOI: 10.1016/j.snb.2012.11.077)

80.        Janrungroatsakul, W.; Vilaivan, T.; Vilaivan, C.; Watchasit, S.; Suksai, C.; Ngeontae, W.; Aeungmaitrepirom, W.; Tuntulani, T. “New calix[4]arene derivatives as ionophores in polymeric membrane electrodes for Ag(I): Comparative selectivity studies and detection of DNA hybridization” Talanta 2013, 105, 1–7. (on-line: 27 Nov 2012, published: Mar 2013) (DOI: 10.1016/j.talanta.2012.11.046)

79.        Laopa, P.S.; Vilaivan, T.; Hoven, V. P. “Positively charged polymer brushes-functionalized filter paper for DNA sequence determination following Dot Blot hybridization employing pyrrolidinyl peptide nucleic acid probe” Analyst 2013, 138, 269–277. (on-line: 19 Oct 2012; published: 07 Jan 2013) (DOI: 10 .1039/c2an36 133g)

78.        Sopitthummakhun, K.; Thongpanchang, C.; Vilaivan, T.; Yuthavong, Y.; Chaiyen, P.; Leartsakulpanich, U. “Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay” Malaria J. 2012, 11, 194. (on-line: 12 June 2012) (DOI: 10.1186/1475-2875-11-194)

77.        Yuthavong, Y.; Tarnchompoo, B.; Vilaivan, T.; Chitnumsub, P.; Kamchonwongpaisan, S.; Charman, S.A.; McLennan, D.N.; White, K.L.; Vivas, L.; Bongard, E.; Thongphanchang, C.; Taweechai, S.; Vanichtanankul, J.; Rattanajak, R.; Arwon, U.; Fantauzzi, P.; Yuvaniyama, J.; Charman, W.N.; Matthews, D. “Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target” Proc. Natl. Acad. Sci. USA. 2012, 109(42), 16823–16828. (on-line: 03 Oct 2012; published: 16 Oct 2012) (DOI: 10.1073/pnas.1204556109)

76.        Siripornnoppakhun, W.; Niamnont, N.; Krumsri, A.; Tumcharern, G.; Vilaivan, T.; Rashatasakhon, P.; Thayumanavan, S.; Sukwattanasinitt, M. “Inclusion complexes between amphiphilic phenyleneethynylene fluorophores and cyclodextrins in aqueous media” J. Phys. Chem. B 2012, 116, 12268–12274. (on-line: 26 Sep 2012; published: 11 Oct 2012) (DOI: 10.1021/jp3057652)

75.        Sezi, S.; Varghese, R.; Vilaivan, T.; Wagenknecht, H.-A. “Conformational control of dual emission by pyrrolidinyl PNA–DNA hybrids” ChemistryOpen 2012, 1, 173–176. (on-line: 11 Jul 2012; published: August 2012) (DOI: 10.1002/open.201200016)

74.        Thipmanee, O.; Samanman, S.; Sankoh, S.; Numnuam, A.; Limbut, W.; Kanatharana, P.; Vilaivan, T.; Thavarungkul, P. “Label-free capacitive DNA sensor using immobilized pyrrolidinyl PNA probe: Effect of the length and terminating head group of the blocking thiols” Biosens. Bioelectron. 2012, 38, 430–435. (on-line: 09 Jun 2012 published: Dec 2012) (DOI: 10.1016/j.bios.2012.06.021)

73.        Vanichtanankul, J.; Taweechai, S.; Uttamapinant, C.; Chitnumsub, P.; Vilaivan, T.; Yuthavong, Y.; Kamchonwongpaisan, S. “Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil” Antimicrobial Agents and Chemotherapy 2012, 56(7), 3928–3935. (on-line: 23 Apr 2012; published: Jul 2012) (DOI: 10.1128/AAC.00301-12)

72.        Mansawat, W.; Boonlua, C.; Siriwong, K.; Vilaivan, T. “Clicked polycyclic aromatic hydrocarbon as a hybridization-responsive fluorescent artificial nucleobase in pyrrolidinyl peptide nucleic acids” Tetrahedron 2012, 68(21), 3988–3995. (on-line: 28 Mar 2012; published: 27 May 2012) (DOI: 10.1016/j.tet.2012.03.062)

71.        Mansawat, W.; Vilaivan, C.; Balázs, Á.; Aitken, D.; Vilaivan, T. “Pyrrolidinyl peptide nucleic acid homologues: Effect of ring size on hybridization properties” Org. Lett. 2012, 14, 1440–1443. (on-line: 29 Feb 2012; published: 16 Mar 2012) (DOI: 10.1021/ol300190u)

70.        Virakul, S.; Kupatawintu, P.; Nakkuntod, J.; Kangwanshiratada, O.; Vilaivan, T.; Hirankarn, N. “A nested sequence-specific primer-polymerase chain reaction for the detection of HLA-B*15:02Tissue Antigens 2012, 79(4), 295–301. (on-line: 28 Jan 2012; published: April 2012) (DOI: 10.1111/j.1399-0039.2012.01836.x)

69.        Yuanboonlim, W.; Siripornnoppakhun, W.; Niamnont, N.; Rashatasakhon, P.; Vilaivan, T.; Sukwattanasinitt, M. “Phenylene–ethynylene trication as an efficient fluorescent signal transducer in an aptasensor for potassium ion” Biosens. Bioelectron. 2012, 33, 1918–1923. (on-line: 30 Dec 2011 published: 15 March 2012) (DOI: 10.1016/j.bios.2011.11.049)

68.        Rashatasakhon, P.; Vongnam, K.; Siripornnoppakhun, W.; Vilaivan, T.; Sukwattanasinitt, M. “FRET detection of DNA sequence via electrostatic interaction of polycationic phenyleneethynylene dendrimer with DNA/PNA hybrid” Talanta 2012, 88, 593–598. (on-line 19 Nov 2011, published: 15 Jan 2012) (DOI: 10.1016/j.talanta.2011.11.041)

67.        Pudhom, K.; Nuanyai, T.; Matsubara, K.; Vilaivan, T. “Antiangiogenic activity of 3,4-seco-cycloartane triterpenes from Thai Gardenia spp. and their semi-synthetic analogs” Bioorg. Med. Chem. Lett. 2012, 22, 512–517. (on-line 16 Nov 2011, published: 1 Jan 2012) (DOI: 10.1016/j.bmcl.2011.10.128)

66.        Rutnakornpituk, B.; Wichai, U.; Vilaivan, T.; Rutnakornpituk, M. “Surface-initiated atom transfer radical polymerization of poly(4-vinylpyridine) from magnetite nanoparticle” J. Nanopart. Res. 2011, 13, 6847–6857. (on-line 7 Oct 2011, published: 14 Dec 2011) (DOI: 10.1007/s11051-011-0592-8)

65.        Boonlua, C.; Vilaivan, C.; Wagenknecht, H.-A.; Vilaivan, T. “5-(Pyren-1-yl)uracil as a base-discriminating fluorescent nucleobase in pyrrolidinyl peptide nucleic acids” Chem. Asian J. 2011, 6, 3251–3259. (on-line 26 Sep 2011, published: 2 Dec 2011) (DOI: 10.1002/asia.201100490)

64.        Reenabthue, N.; Boonlua, C.; Vilaivan C.; Vilaivan, T.; Suparpprom, C. “3-Aminopyrrolidine-4-carboxylic acid as versatile handle for internal labeling of pyrrolidinyl PNA” Bioorg. Med. Chem. Lett. 2011, 21, 6465–6469. (on-line 23 Aug 2011, published: 1 Nov 2011) (DOI: 10.1016/j.bmcl.2011.08.079)

63.        Vanichtanankul, J.; Taweechai, S.; Yuvaniyama, J.; Vilaivan, T.; Chitnumsub, P.; Kamchonwongpaisan, S.; Yuthavong, Y. “Trypanosomal dihydrofolate reductase reveals natural antifolate resistance” ACS Chem. Biol. 2011, 6, 905–911. (on-line 8 June 2011, published: Sep 2011) (DOI: 10.1021/cb200124r)

62.        Sangthong, S.; Krusong, K.; Ngamrojanavanich, N.; Vilaivan, T.; Puthong, S.; Chandchawan, S.; Muangsin, N. “Synthesis of rotenoid derivatives with cytotoxic and topoisomerase II inhibitory activities” Bioorg. Med. Chem. Lett. 2011, 21, 4813–4818. (published: 15 Aug 2011) (DOI: 10.1016/j.bmcl.2011.06.052)

61.        Vilaivan, C.; Srisuwannaket, C.; Ananthanawat, C.; Suparpprom, C.; Kawakami, J.; Yamaguchi, Y.; Tanaka, Y.; Vilaivan, T. “Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone: A conformationally constrained PNA with unusual hybridization properties” Artificial DNA: PNA & XNA 2011, 2, 50–59. (published: July 2011) (DOI: 10.4161/adna.2.2.16340)

60.        Nuanyai T., Sappapan R., Vilaivan T., Pudhom, K. “Dammarane triterpenes from the apical buds of Gardenia collinsaePhytochemistry Lett. 2011, 4, 183–186. (published: 15 Jun 2011) (DOI: 10.1016/j.phytol.2011.03.001)

59.        Nuanyai T., Sappapan R., Vilaivan T., Pudhom, K. “Cycloartane triterpenes from the exudate of Gardenia thailandicaPhytochemistry Lett. 2011, 4, 26–29. (published: 15 Mar 2011) (DOI: 10.1016/j.phytol.2010.10.003)

58.        Nuanyai T., Sappapan R., Vilaivan T., Pudhom, K. “Gardenoins E-H, Cycloartane triterpenes from the apical buds of Gardenia obtusifoliaChem. Pharm. Bull. 2011, 59, 385–387. (published: Mar 2011)

57.        Ngamwiriyawong, P. Vilaivan, T. “Synthesis and nucleic acids binding properties of diastereomeric aminoethylprolyl peptide nucleic acids (aepPNA)” Nucleosides Nucleotides and Nucleic Acids 2011, 30, 97–112. (on-line: 24 Feb 11) (DOI: 10.1080/15257770.2010.547839)

56.        Ananthanawat, C.; Hoven, V. P.; Vilaivan, T.; Su, X. “Surface plasmon resonance study of PNA interactions with double-stranded DNA “ Biosens. Bioelectron. 2011, 26, 1918–1923. (on-line: 8 Jun 10) (DOI: 10.1016/j.bios.2010.05.027)

55.        Taechalertpaisarn, J.; Sriwarom, P.; Boonlua, C.; Yotapan, N.; Vilaivan, C.; Vilaivan, T. “DNA-, RNA- and self-pairing properties of a pyrrolidinyl peptide nucleic acid with a (2'R,4'S)-prolyl-(1S,2S)-2-aminocyclopentanecarboxylic acid backbone” Tetrahedron Lett 2010, 51, 5822–5826. (on-line: 6 Sep 10; in print: 03 Nov 2010) (DOI: 10.1016/j.tetlet.2010.08.102)

54.        Vilaivan, T.; Bhanthumnavin, W. “Organocatalyzed asymmetric α-oxidation, α-aminoxylation and α-amination of carbonyl compounds” Molecules 2010, 15, 917–958. (on-line: 11 Feb 10) (DOI: 10.3390/molecules15020917)

53.        Nuanyai, T.; Chokpaiboon, S.; Vilaivan, T.; Pudhom, K. “Cytotoxic 3,4-seco-cycloartane triterpenes from the exudate of Gardenia tubiferaJ. Nat. Prod. 2010, 73, 51–54. (on-line: 12 Dec 09; in print: 22 Jan 10) (DOI: 10.1021/np900658t)

52.        Ananthanawat, C.; Vilaivan, T.; Hoven, V. P.; Su, X. “Comparison of DNA, aminoethylglycyl PNA and pyrrolidinyl PNA as probes for detection of DNA hybridization using surface plasmon resonance technique” Biosens. Bioelectron. 2010, 25, 1064–1069. (on-line: 1 Oct 09; in print: 15 Jan 10) (DOI: 10.1016/j.bios.2009.09.028)

51.        Chitnumsub, P.; Yuvaniyama,J.; Chahomchuen, T.; Vilaivan, T.; Yuthavong, Y. “Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen” Acta Cryst. 2009, F65, 1175–1178. (DOI: 10.1107/S1744309109041979)

50.        Ananthanawat, C.; Vilaivan, T.; Mekboonsonglarp, W.; Hoven, V. P. “Thiolated pyrrolidinyl peptide nucleic acids for the detection of DNA hybridization using surface plasmon resonance” Biosens. Bioelectron. 2009, 24, 3544–3549. (on-line: 18 May 09; in print: 15 August 2009). (DOI: 10.1016/j.bios.2009.05.011)

49.        Banphavichit, V.; Mansawat, W.; Bhanthumnavin, W.; Vilaivan, T. “A practical synthesis of optically active arylglycines via catalytic asymmetric Strecker reaction” Tetrahedron 2009, 65, 5849–5854. (on-line: 8 May 09; in print: 18 July 2009). (DOI: 10.1016/j.tet.2009.04.098)

48.        Maitarad, P.; Kamchonwongpaisan, S.; Vanichtanankul, J.; Vilaivan, T.; Yuthavong, Y.; Hannongbua, S. “Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases” J. Comput. Aided Mol. Des. 2009, 23, 241–252.

47.        Ananthanawat, C.; Vilaivan, T.; Hoven, V.P. “Synthesis and immobilization of thiolated pyrrolidinyl peptide nucleic acids on gold-coated piezoelectric quartz crystals for the detection of DNA hybridization” Sens. Actuators B: Chem. 2009, 137(1), 215–221.

46.        Boontha B.; Nakkuntod, J.; Hirankarn, N.; Chaumpluk, P.;Vilaivan, T. “Multiplex mass spectrometric genotyping of single nucleotide polymorphisms employing pyrrolidinyl peptide nucleic acid in combination with ion-exchange capture” Anal. Chem. 2008, 80(21), 8178–8186.

45.        Siriwong, K.; Chuichay, P.; Saen-oon, S.; Suparpprom, C.; Vilaivan, T.; Hannongbua, S. “Insight into why pyrrolidinyl peptide nucleic acid binding to DNA is more stable than the DNA·DNA duplex” Biochem. Biophys. Res. Commun. 2008, 372, 765–771.

44.        Sathapornvajana, S.; Vilaivan, T. “Prolinamides derived from aminophenols as organocatalysts for asymmetric direct aldol reactions” Tetrahedron 2007, 63(41), 10253–10259.

43.        Banphavichit, V.; Bhanthumnavin, W.; Vilaivan, T. “Synthesis of new tridentate chiral aminoalcohols by a multicomponent reaction and their evaluation as ligands for catalytic asymmetric Strecker reaction” Tetrahedron 2007, 63(36), 8727–8734.

42.        Mansawat, W.; Saengswang, I.; U-prasitwong, P.; Bhanthumnavin, W.; Vilaivan, T. “Novel thiolated amino-alcohols as chiral ligands for copper-catalyzed asymmetric nitro-aldol reactions” Tetrahedron Lett. 2007, 48(24), 4235–4238.

41.        Pudhom, K.; Vilaivan, T.; Ngamrojanavanich, N.; Dechangvipart, S.; Sommit, D.; Petsom, A.; Roengsumran, S.” Furanocembranoids from the stem bark of Croton oblongifoliusJ. Nat. Prod. 2007, 70(4), 659–661.

40.        Vilaivan, T. “A rate enhancement of tert-butoxycarbonylation of aromatic amines with Boc2O in alcoholic solvents” Tetrahedron Lett. 2006, 47(38), 6739–6742.

39.        Ananthanawat, C.; Banphavichit, V.; Vilaivan, T. “Convenient procedure for synthesis of N-protected b-aminomalonates and b-amino acids from a-amidosulfones” Synth. Commun. 2006, 36(13), 1845–1855.

38.        Vilaivan, T.; Srisuwannaket, C. “Hybridization of pyrrolidinyl peptide nucleic acids and DNA: Selectivity, base-pairing specificity, and direction of binding” Org. Lett. 2006, 8(9), 1897–1900.

37.        Vilaivan, T.; Bhanthumnavin, W.; Sritana-Anant, Y. “Recent advances in catalytic asymmetric addition to imines and related C=N systems” Curr. Org. Chem. 2005, 9(14), 1315–1392.

36.        Vilaivan, T.; Winotapan, C.; Banphavichit, V.; Shinada, T.; Ohfune, Y. “Indium-mediated asymmetric Barbier-type allylation of aldimines in alcoholic solvents: Synthesis of optically active homoallylic amines” J. Org. Chem. 2005, 70(9), 3464–3471.

35.        Suparpprom, C.; Srisuwannaket, C.; Sangvanich, P.; Vilaivan, T. “Synthesis and oligodeoxynucleotide binding properties of pyrrolidinyl peptide nucleic acids bearing prolyl-2-aminocyclopentanecarboxylic acid (ACPC) backbones” Tetrahedron Lett. 2005, 46(16), 2833–2837.

34.        Yuthavong, Y.; Yuvaniyama, J.; Chitnumsub, P.; Vanichtanankul, J.; Chusacultanachai, S.; Tarnchompoo, B.; Vilaivan, T.; Kamchonwongpaisan, S. “Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors” Parasitology 2005, 130, 249–259.

33.        Banphavichit, V.; Mansawat, W.; Bhanthumnavin, W.; Vilaivan, T. “A highly enantioselective Strecker reaction catalyzed by titanium-N-salicyl-b-aminoalcohol complexes” Tetrahedron 2004, 60(46), 10559–10568. (Tetrahedron Symposia-in-Print: Synthesis and Applications of Non-Racemic Cyanohydrins and alpha-Amino Nitriles)

32.        Banphavichit, V.; Chaleawlertumpon, S.; Bhanthumnavin, W.; Vilaivan, T. “A convenient synthesis of N-Boc-protected a-aminonitriles from a-amidosulfones” Synth. Commun. 2004, 34(17), 3147–3160.

31.        Kamchonwongpaisan, S.; Quarrell, R.; Charoensethakul, N.; Ponsinet, R.; Vilaivan, T.; Vanichtanankul, J.; Tarnchompoo, B.; Sirawaraporn, W.; Lowe, G.; Yutavong, Y. “Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities” J. Med. Chem. 2004, 47, 673–680.

30.        Janwitayanuchit, W; Suwanborirux, K.; Patarapanich, C.; Pummangura, S.; Lipipun, V.; Vilaivan, T. “Synthesis and anti-herpes simplex viral activity of monoglycosyl diglycerides” Phytochemistry 2003, 64, 1253 –1264.

29.        Mansawat, W.; Bhanthumnavin, W.; Vilaivan, T. “N-Salicyl-b-aminoalcohols as a new class of ligand for catalytic asymmetric Strecker reactions” Tetrahedron Lett. 2003, 44(19), 3805–3808.

28.        Vilaivan, T.; Suparpprom, C.; Duanglaor, P.; Harnyuttanakorn, P.; Lowe, G. “Synthesis and nucleic acid binding studies of novel pyrrolidinyl PNA carrying an N-amino-N-methylglycine spacer” Tetrahedron Lett. 2003, 44(8), 1663–1666.

27.        Vilaivan, T.; Saesaengseerung, N.; Jarprung, D; Kamchonwongpaisan, S.; Sirawaraporn, W.; Yuthavong, Y. “Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparumBioorg. Med. Chem. 2003, 11(2), 217–224.

26.        Vilaivan, T.; Lowe, G. “A novel pyrrolidinyl PNA showing high sequence specificity and preferential binding to DNA over RNA” J. Am. Chem. Soc. 2002, 124(32), 9326–9327.

25.        Saesaengseerung, N.; Vilaivan, T.; Thebtaranonth, Y. “An efficient synthesis of 1-aryl-4,6-diamino-1,2-dihydro- 1,3,5-triazines” Synth. Commun. 2002, 32(14), 2089–2100.

24.        Roengsumran, S.; Musikul, K.; Petsom, A.; Vilaivan, T.; Sangvanich, P. ; Pornpakakul, S.; Puthong, S.; Chaichantipyuth, C.; Jaiboon, N.; Chaichit, N. “Croblongifolin, a new anticancer clerodane from Croton oblongifolius”, Planta Med. 2002, 68(3), 274–277.

23.        Vilaivan, T.; Winotapan, C.; Shinada, T.; Ohfune, Y. “Indium mediated Barbier-type allylation of aldimines in alcoholic solvents” Tetrahedron Lett. 2001, 42(51), 9073–9076.

22.        Suparpprom, C.; Vilaivan, T. “Synthesis of 2-[4'-(ethylcarbamoyl)phenyl]-N-acetylglycine, the proposed structure for giganticine” J. Nat. Prod. 2001, 64(8), 1114–1116.

21.        Vilaivan, T.; Suparpprom, C.; Harnyuttanakorn, P.; Lowe, G. “Synthesis and properties of novel pyrrolidinyl PNA carrying b-amino acid spacers”, Tetrahedron Lett. 2001, 42(32), 5533–5536.

20.        Vilaivan, T.; Khongdeesameor, C.; Wiriyawaree, W.; Mansawat, W.; Westwell, M.S.; Lowe, G. “Synthesis and properties of novel peptide nucleic acids with hydrophilic serine spacers” Science Asia 2001, 27(2), 113–120.

19.        Pudhom, K.; Vilaivan, T. “Pentafluorophenyl 4-nitrobenzenesulfonate as a peptide coupling reagent” Synth. Commun. 2001, 31(1), 61–70.

18.        Roengsumran, S.; Petsom, A.; Kuptiyanuwat, N.; Vilaivan, T.; Ngamrojnavanich, N.; Chaichantipyuth, C.; Phuthong, S. “Cytotoxic labdane diterpenoids from Croton oblongifoliusPhytochemistry 2001, 56(1), 103–107.

17.        Vilaivan, T.; Khongdeesameor, C.; Harnyuttanakorn, P.; Westwell, M.S.; Lowe, G. “Synthesis and properties of chiral peptide nucleic acids with a N-aminoethyl-D-proline backbone” Bioorg. Med. Chem. Lett. 2000, 10(22), 2541–2545.

16.        Yuthavong, Y.; Vilaivan, T.; Chareonsethakul, N.; Kamchonwongpaisan, S.; Sirawaraporn, W.; Quarrell, R.; Lowe, G. “Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil resistant strain (T9/94) of Plasmodium falciparumJ. Med. Chem. 2000, 43, 2738–2744.

15.        Rastelli, G.; Sirawaraporn, W.; Sompornpisut, P.; Vilaivan, T.; Kamchonwongpaisan, S.; Quarrell, R.; Lowe, G.; Thebtaranonth, Y.; Yuthavong, Y. “Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: Structural basis of antifolate resistance” Bioorg. Med. Chem. 2000, 8, 1117–1128.

14.        Sithigorngul, P.; Panchan, N.; Vilaivan, T.; Sithigorngul, W.; Petsom, A. “Immunochemical analysis and immunocytochemical localization of crustacean hyperglycemic hormone from the eyestalk of Macrobrachium rosenbergiiComp. Biochem. Phys. B 1999, 124(1), 73–80.

13.        Lowe, G.; Droz, A.S.; Vilaivan, T.; Weaver, G.W.; Park, J.J.; Pratt, J.M. Tweedale, L.; Kelland, L.R. “Cytotoxicity of (2,2':6',2”-terpyridine)platinum(II) complexes against Human Ovarian Carcinoma” J. Med. Chem. 1999, 42, 3167–3174.

12.        Pudhom, K.; Vilaivan, T. “Synthesis of aryl esters of protected amino acids from aryl sulfonates” Tetrahedron Lett. 1999, 40(32), 5939–5942.

11.        Lowe, G.; Droz, A.S.; Vilaivan, T.; Weaver, G.W.; Tweedale, L.; Pratt, J.M.; Rock, P.; Yardley, V.; Croft, S.L. “Cytotoxicity of (2,2':6',2”-terpyridine)platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi and Trypanosoma bruceiJ. Med. Chem. 1999, 42(6), 999–1006.

10.        Roengsumran, S.; Petsom, A.; Sommit, D.; Vilaivan, T. “New labdane diterpenoids from Croton oblongifoliusPhytochemistry 1999, 50, 449–453.

9.          Roengsumran, S.; Achayindee, S.; Petsom, A.; Pudhom, K.; Singtothong, P.; Surachetapan, C.; Vilaivan, T. “Two new cembranoids from Croton oblongifoliusJ. Nat. Prod. 1998, 61(5), 652–654.

8.          Lowe, G.; Vilaivan, T.; Westwell, M.S. “Hybridization studies with chiral peptide nucleic acids” Bioorg. Chem. 1997, 25(5-6), 321–329.

7.          Lowe, G.; Vilaivan, T. “Solid phase synthesis of novel peptide nucleic acids” J. Chem. Soc., Perkin Trans. I 1997, 555–560.

6.          Lowe, G.; Vilaivan, T. “Dipeptides bearing nucleobases for synthesis of novel peptide nucleic acids” J. Chem. Soc., Perkin Trans. I 1997, 547–554.

5.          Lowe, G.; Vilaivan, T. “Amino acids bearing nucleobases for synthesis of novel peptide nucleic acids” J. Chem. Soc., Perkin Trans. I 1997, 539–546.

4.          Charnega, A.; Droz, A.S.; Prout, K.; Vilaivan, T.; Weaver, G.W.; Lowe, G. “Structural evidence for the reactivity of 4-picoline(2,2':6',2”-terpyridine)platinum(II) complexes and evidence for -stacking in the crystal lattice” J. Chem. Res.(S) 1996, 402–403.

3.          Lowe, G.; Vilaivan, T. “ An improved method for the synthesis of (2,2':6',2”-terpyridine)platinum(II) complexes” J. Chem. Res.(S) 1996, 386–387.

2.          Lowe, G.; Vilaivan, T. “ Reaction of 4-picoline(2,2':6',2”-terpyridine)platinum(II) with nucleosides” J. Chem. Soc., Perkin Trans I 1996, 1499–1503.

1.          Lowe, G.; McCloskey, J.A.; Ni, J.; Vilaivan, T. “A mass spectrometric investigation of the reaction between 4,4'-vinylidenedipyridine bis[2,2':6',2”-terpyridineplatinum(II)] and the self-complementary oligonucleotide d(CpGpTpApCpG)” Bioorg. Med. Chem. 1996, 4, 1007–1013.